Reply to Braasch and Postlethwait: Evolutionary origin of the teleost A2 agouti genes (agouti signaling protein 2 and agouti-related protein 2) remains unclear.
نویسندگان
چکیده
منابع مشابه
The teleost agouti-related protein 2 gene is an ohnolog gone missing from the tetrapod genome.
A central question in evolutionary genomics is how morphological differences between taxa arise from differences in gene repertoire. Answers require rigorous orthology assignments. Recent work (1) illuminated the mechanism of background adaptation in teleost fishes by investigating the function of agoutirelated protein 2 (agrp2), a gene so far found only in teleosts. Agouti family proteins anta...
متن کاملIdentification of Distant Agouti-Like Sequences and Re-Evaluation of the Evolutionary History of the Agouti-Related Peptide (AgRP)
The Agouti-like peptides including AgRP, ASIP and the teleost-specific A2 (ASIP2 and AgRP2) peptides have potent and diverse functional roles in feeding, pigmentation and background adaptation mechanisms. There are contradictory theories about the evolution of the Agouti-like peptide family as well the nomenclature. Here we performed comprehensive mining and annotation of vertebrate Agouti-like...
متن کاملComparison of the Agouti Dependent Protein and Neuropeptide Y Response to the High Intensity Interval Training in Obese and Underweight Men
Objective: Appetite regulation has a great impact on energy homeostasis. This study aimed to compare the response agouti-related protein (AGRP) and neuropeptide Y (NPY) to a single high intensity interval training (HIIT) in obese and underweight men. Materials and Methods: This semi-experimental research conducted on 40 obese and underweight men who were divided into four groups including expe...
متن کاملInteraction of Agouti protein with the melanocortin 1 receptor in vitro and in vivo.
Agouti protein and Agouti-related protein (Agrp) are paracrine-signaling molecules that normally regulate pigmentation and body weight, respectively. These proteins antagonize the effects of alpha-melanocyte-stimulating hormone (alpha-MSH) and other melanocortins, and several alternatives have been proposed to explain their biochemical mechanisms of action. We have used a sensitive bioassay bas...
متن کاملDown-regulation of melanocortin receptor signaling mediated by the amino terminus of Agouti protein in Xenopus melanophores.
Agouti protein and Agouti-related protein (Agrp) regulate pigmentation and body weight, respectively, by antagonizing melanocortin receptor signaling. A carboxyl-terminal fragment of Agouti protein, Ser73-Cys131, is sufficient for melanocortin receptor antagonism, but Western blot analysis of skin extracts reveals that the electrophoretic mobility of native Agouti protein corresponds to the mat...
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ورودعنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 108 13 شماره
صفحات -
تاریخ انتشار 2011